產(chǎn)品英文名稱：PE Mouse Anti-Human CD10
產(chǎn)品中文名稱：PE鼠抗人CD10

BD PE鼠抗人CD10 PE Mouse Anti-Human CD10產(chǎn)品英文描述：
Catalog Number  347653
Name  Cytokeratin
Size  100 Tests
Regulatory Status  RUO (GMP)
List Price  Inquire
Related Molecules  KRT7 
Clone  CAM 5.2
Format  FITC
Isotype  IgG2a, κ
W.S. No  none
W.B. Positive Control  none
Molecular Weight  none
Reactivity  QC Testing : Human
Applications  Routinely Tested:Intracellular staining (flow cytometry)
Reacts with neutral endopeptidase, a 100 kDa type II transmembrane glycoprotein, otherwise known as the common acute lymphoblastic
leukemia antigen (CALLA). CD10 is expressed on a wide variety of normal and neoplastic cell types. Normal cells expressing CD10 include
granulocytes, a subset of B-cell progenitors, germinal center cells and fibroblasts.
Clone - Description
Anti-Cytokeratin (CAM 5.2) reagent has a primary reactivity with human keratin proteins that correspond to Moll`s peptides #7 and #8, Mr 48 and 52 kDa, respectively.Cytokeratin 7 and 8 are present on secretory epithelia of normal human tissue but not on stratified squamous epithelium. Anti-Cytokeratin (CAM 5.2) stains most epithelial-derived tissue, including liver, renal tubular epithelium, and hepatocellular and renal cell carcinomas. Anti-Cytokeratin (CAM 5.2) may not react with some squamous cell carcinomas.
 

BD PE鼠抗人CD10 PE Mouse Anti-Human CD10單克隆抗體多樣性的遺傳學(xué)基礎(chǔ)：
L鏈H鏈相互隨機(jī)配對(duì) 如表2-6所示，小鼠H鏈和κ鏈隨機(jī)配對(duì)后推算其多樣性可達(dá)4.8×107，如果再加上H鏈與λ鏈的隨機(jī)配對(duì)其多樣性應(yīng)更多了。
產(chǎn)品規(guī)格：0.1ml/0.2ml
儲(chǔ) 存： -20℃環(huán)境下存放. 封閉保存,否則會(huì)降低產(chǎn)品含量.
產(chǎn)品用途：本產(chǎn)品僅供科研使用，不做其他用途
產(chǎn)品價(jià)格：電詢咨詢
 

基因重排：
1）抗體的L鏈?zhǔn)怯蒀、V、J三個(gè)基因簇編碼的，H鏈由C、V、D、J四個(gè)基因簇編碼的。
2）V是編碼可變區(qū)，有300個(gè)種類;D編碼高變區(qū),有15 ～ 20個(gè)種類;J編碼連接V、C的結(jié)合區(qū)，有4～5個(gè)種類;C編碼恒定區(qū)，僅有一種。
3）這些外顯子通過多種多樣的重排，所合成出的肽鏈，還要再進(jìn)一步進(jìn)行L和H鏈組合，這樣zui后生成的抗體種類就非常多了。
4）抗體基因重排是發(fā)生在淋巴細(xì)胞分化的時(shí)候

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